Snježana Lelas

Different GABA _A receptor subtypes mediate the anxiolytic, abuse-related, and motor effects of benzodiazepine-like drugs in primates

James K. Rowlett, Donna M. Platt, Snježana Lelas et al. · Proceedings of the National Academy of Sciences · 2005 · 206 citations · Full text

Synthesis and Structure−Activity Relationships of 8-(Pyrid-3-yl)pyrazolo[1,5-<i>a</i>]-1,3,5-triazines: Potent, Orally Bioavailable Corticotropin Releasing Factor Receptor-1 (CRF₁) Antagonists

Paul J. Gilligan, Todd Clarke, Liqi He et al. · Journal of Medicinal Chemistry · 2009 · 58 citations · Full text

Receptor Antagonists, Psychopharmacology, Compound 13-15 +17

Anxiolytic-Like Effects of the Corticotropin-Releasing Factor1 (CRF1) Antagonist DMP904 [4-(3-pentylamino)-2,7-dimethyl-8-(2-methyl-4-methoxyphenyl)-pyrazolo-[1,5-a]-pyrimidine] Administered Acutely or Chronically at Doses Occupying Central CRF1 Receptors in Rats

Snježana Lelas, Harvey Wong, Yu-Wen Li et al. · Journal of Pharmacology and Experimental Therapeutics · 2004 · 55 citations

A Strategy to Minimize Reactive Metabolite Formation: Discovery of (<i>S</i>)-4-(1-Cyclopropyl-2-methoxyethyl)-6-[6-(difluoromethoxy)-2,5-dimethylpyridin-3-ylamino]-5-oxo-4,5-dihydropyrazine-2-carbonitrile as a Potent, Orally Bioavailable Corticotropin-Releasing Factor-1 Receptor Antagonist

Richard A. Hartz, Vijay T. Ahuja, Xiaoliang Zhuo et al. · Journal of Medicinal Chemistry · 2009 · 54 citations · Full text

Pharmaceutical Science, Metabolic Characterization, Receptor Antagonist +16

The CRF 1 receptor antagonist DMP696 produces anxiolytic effects and inhibits the stress-induced hypothalamic-pituitary-adrenal axis activation without sedation or ataxia in rats

John Mcelroy, Kim Zeller, Keith Jones et al. · Psychopharmacology · 2002 · 42 citations

Adrenal Gland, Stress Hormone, Crf 1 +13