Concepedia

Receptor Occupancy Analysis

Receptor Occupancy Analysis is a quantitative pharmacological method that measures the proportion of target receptors bound by a drug at a given time to assess target engagement and inform dosage optimization in translational drug development.

575

Publications

32.9K

Citations

3K

Authors

741

Institutions

Publications per year

2017–2026

60

Parents

Publications

575

Relationship Between Dopamine D<sub>2</sub> Occupancy, Clinical Response, and Side Effects: A Double-Blind PET Study of First-Episode Schizophrenia

Shitij Kapur, Robert B. Zipursky, Corey Jones et al. · American Journal of Psychiatry · 2000 · 1.1K citations

, , +17

First-in-Human, First-in-Class Phase I Trial of the Anti-CD47 Antibody Hu5F9-G4 in Patients With Advanced Cancers

Branimir I. Šikić, Nehal J. Lakhani, Amita Patnaik et al. · Journal of Clinical Oncology · 2019 · 590 citations · Full text

, , +17

Psychedelic effects of psilocybin correlate with serotonin 2A receptor occupancy and plasma psilocin levels

M. Madsen, Patrick M. Fisher, Daniel Burmester et al. · Neuropsychopharmacology · 2019 · 500 citations · Full text

, , +15

Different responses are elicited in cytotoxic T lymphocytes by different levels of T cell receptor occupancy.

Salvatore Valitutti, Sabina Müller, Mark C. Dessing et al. · The Journal of Experimental Medicine · 1996 · 438 citations · Full text

, , +16

Influence of Phasic and Tonic Dopamine Release on Receptor Activation

Jakob Kisbye Dreyer, Kjartan F. Herrik, Rune W. Berg et al. · Journal of Neuroscience · 2010 · 432 citations · Full text

, , +17

1–5 of 575

Authors

3K

  1. CH
    Christer Halldin

    Karolinska Institutet, Sweden

    20 publications · 1.1K citations

    18

    h-index

  2. LF
    Lars Farde

    Karolinska Institutet, Sweden

    20 publications · 1.5K citations

    18

    h-index

  3. SK
    Shitij Kapur

    University of Toronto, Canada

    18 publications · 2.5K citations

    17

    h-index

  4. TI
    Tatsuji Iga

    The University of Tokyo, Japan

    11 publications · 258 citations

    11

    h-index

  5. YS
    Yasufumi Sawada

    The University of Tokyo, Japan

    12 publications · 417 citations

    11

    h-index

1–5 of 3K

Institutions

741

  1. Karolinska Institutet

    Stockholm, Sweden

    20 h-index

    70 publications

    2.9K citations

  2. University of Toronto

    Toronto, Canada

    17 h-index

    69 publications

    4.9K citations

  3. Centre for Addiction and Mental Health

    Toronto, Canada

    15 h-index

    66 publications

    2.8K citations

  4. National Institutes of Health

    Bethesda, United States

    14 h-index

    64 publications

    2.6K citations

  5. Hammersmith Hospital

    London, United Kingdom

    14 h-index

    76 publications

    6.7K citations

  6. Imperial College London

    London, United Kingdom

    14 h-index

    44 publications

    3.9K citations

  7. GlaxoSmithKline (United Kingdom)

    London, United Kingdom

    13 h-index

    52 publications

    3.1K citations

  8. Yale University

    New Haven, United States

    13 h-index

    106 publications

    5.3K citations

1–8 of 741

Venues

  1. 24

    h-index

  2. Journal of Biological Chemistry

    JBC · 25 publications · 2.4K citations

    24

    h-index

  3. PubMed

    Repository · 32 publications · 1.4K citations

    21

    h-index

  4. Psychopharmacology

    19 publications · 1.3K citations

    17

    h-index

  5. Endocrinology

    20 publications · 1.3K citations

    16

    h-index

1–5