Concepedia

Brain Exposure

Brain Exposure is a quantitative measure of the extent to which a substance, typically a drug or therapeutic agent, reaches the brain parenchyma following systemic administration, distinguished by its focus on the concentration-time profile of the compound within the central nervous system relative to its exposure in the periphery.

467

Publications

25.7K

Citations

3K

Authors

824

Institutions

Publications per year

2017–2026

125

Parents

Publications

467

Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure

Xuyu Qian, Ha Nam Nguyen, Mingxi M. Song et al. · Cell · 2016 · 2.2K citations · Full text

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TGF-  receptor-mediated albumin uptake into astrocytes is involved in neocortical epileptogenesis

Sebastian Ivens, Daniela Kaufer, Laura Flores et al. · Brain · 2006 · 547 citations · Full text

, , +17

Plasma and Cerebrospinal Fluid Population Pharmacokinetics of Temozolomide in Malignant Glioma Patients

Sandrine Ostermann, Chantal Csajka, Thierry Buclin et al. · Clinical Cancer Research · 2004 · 513 citations · Full text

, , +16

Influence of nonspecific brain and plasma binding on CNS exposure: implications for rational drug discovery

J. Cory Kalvass, Tristan S. Maurer · Biopharmaceutics & Drug Disposition · 2002 · 415 citations

, , +15

Intermittent ethanol exposure induces inflammatory brain damage and causes long‐term behavioural alterations in adolescent rats

María Pascual, Ana María Andrés Blanco, Omar Cauli et al. · European Journal of Neuroscience · 2007 · 383 citations

, , +14

1–5 of 467

Authors

3K

  1. JW
    Joe Wiart

    Orange (France), France

    5 publications · 144 citations

    5

    h-index

  2. KV
    Katarina Varnäs

    Karolinska Institutet, Sweden

    5 publications · 204 citations

    5

    h-index

  3. MS
    Magnus Schou

    Karolinska Institutet, Sweden

    5 publications · 190 citations

    5

    h-index

  4. LF
    Lars Farde

    Karolinska Institutet, Sweden

    5 publications · 204 citations

    5

    h-index

  5. CH
    Christer Halldin

    Karolinska Institutet, Sweden

    5 publications · 204 citations

    5

    h-index

1–5 of 3K

Institutions

824

  1. Inserm

    Paris, France

    13 h-index

    32 publications

    731 citations

  2. Centre National de la Recherche Scientifique

    Paris, France

    12 h-index

    56 publications

    1.8K citations

  3. Research Triangle Park Foundation

    Durham, United States

    9 h-index

    15 publications

    379 citations

  4. AstraZeneca (Sweden)

    Södertälje, Sweden

    9 h-index

    56 publications

    3.7K citations

  5. Indiana University – Purdue University Indianapolis

    Indianapolis, United States

    8 h-index

    31 publications

    1.3K citations

  6. University of Florida

    Gainesville, United States

    8 h-index

    38 publications

    2.5K citations

  7. University of North Carolina at Chapel Hill

    Chapel Hill, United States

    8 h-index

    15 publications

    247 citations

  8. Karolinska Institutet

    Stockholm, Sweden

    7 h-index

    47 publications

    2.1K citations

1–8 of 824

Venues

  1. Journal of Medicinal Chemistry

    24 publications · 1.7K citations

    22

    h-index

  2. PubMed

    Repository · 18 publications · 591 citations

    13

    h-index

  3. NeuroToxicology

    11 publications · 467 citations

    11

    h-index

  4. 9

    h-index

  5. Drug Metabolism and Disposition

    8 publications · 624 citations

    8

    h-index

1–5