Concepedia

Receptor Occupancy Studies

Receptor Occupancy Studies is a radiotracer-based experimental methodology in neuroimaging and pharmacology that quantifies the proportion of specific receptor sites bound by a drug or endogenous ligand in vivo, thereby distinguishing it from indirect measures of receptor function by directly assessing target engagement through positron emission tomography or single-photon emission computed tomography.

1.1K

Publications

63.4K

Citations

5.1K

Authors

1K

Institutions

Publications per year

2017–2026

107

Parents

Publications

1.1K

Relationship Between Dopamine D<sub>2</sub> Occupancy, Clinical Response, and Side Effects: A Double-Blind PET Study of First-Episode Schizophrenia

Shitij Kapur, Robert B. Zipursky, Corey Jones et al. · American Journal of Psychiatry · 2000 · 1.1K citations

, , +17

Synergistic Roles for Receptor Occupancy and Aggregation in Integrin Transmembrane Function

Shingo Miyamoto, Steven K. Akiyama, Kenneth M. Yamada · Science · 1995 · 894 citations

, , +17

Identification and distribution of 5-HT3 receptors in rat brain using radioligand binding

Gavin J. Kilpatrick, Brian Jones, M.B. Tyers · Nature · 1987 · 866 citations

, , +13

Quantitative Analysis of D2 Dopamine Receptor Binding in the Living Human Brain by PET

Lars Farde, Håkan Hall, E. Ehrin et al. · Science · 1986 · 842 citations

, , +16

Site-site interactions among insulin receptors. Characterization of the negative cooperativity.

A R Bainco, Jesse Roth · Journal of Biological Chemistry · 1976 · 604 citations · Full text

, , +17

1–5 of 1.1K

Authors

5.1K

  1. LF
    Lars Farde

    Karolinska Institutet, Sweden

    55 publications · 4.9K citations

    36

    h-index

  2. CH
    Christer Halldin

    Karolinska Institutet, Sweden

    47 publications · 3.1K citations

    32

    h-index

  3. SK
    Shitij Kapur

    University of Toronto, Canada

    32 publications · 3.5K citations

    28

    h-index

  4. AA
    Alan A. Wilson

    Centre for Addiction and Mental Health, Canada

    20 publications · 1.7K citations

    18

    h-index

  5. DF
    Dean F. Wong

    Johns Hopkins University, United States

    17 publications · 1.1K citations

    16

    h-index

1–5 of 5.1K

Institutions

1K

  1. Karolinska Institutet

    Stockholm, Sweden

    37 h-index

    227 publications

    15.5K citations

  2. Hammersmith Hospital

    London, United Kingdom

    30 h-index

    154 publications

    10.5K citations

  3. University of Toronto

    Toronto, Canada

    28 h-index

    144 publications

    9K citations

  4. Karolinska University Hospital

    Stockholm, Sweden

    26 h-index

    80 publications

    6.7K citations

  5. Yale University

    New Haven, United States

    23 h-index

    237 publications

    13.2K citations

  6. Centre for Addiction and Mental Health

    Toronto, Canada

    23 h-index

    133 publications

    6.2K citations

  7. Johns Hopkins University

    Baltimore, United States

    22 h-index

    110 publications

    11.4K citations

  8. Eli Lilly (United States)

    Indianapolis, United States

    19 h-index

    144 publications

    7.1K citations

1–8 of 1K

Venues

  1. 31

    h-index

  2. Psychopharmacology

    40 publications · 2.6K citations

    29

    h-index

  3. Journal of Cerebral Blood Flow & Metabolism

    40 publications · 3.2K citations

    29

    h-index

  4. Journal of Biological Chemistry

    JBC · 31 publications · 3.2K citations

    28

    h-index

  5. PubMed

    Repository · 56 publications · 2.6K citations

    26

    h-index

1–5