Epigenetic targeting of Hedgehog pathway transcriptional output through BET bromodomain inhibition

Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles

Aravind Subramanian, Pablo Tamayo, Vamsi K. Mootha et al. · Proceedings of the National Academy of Sciences · 2005 · 54.5K citations · Full text

Genetics, Genomics, Gene Recognition +23

Master Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes

Warren A. Whyte, David A. Orlando, Denes Hnisz et al. · Cell · 2013 · 4.2K citations · Full text

Transcriptional Regulation, Developmental Biology, Cell Regulation +9

Selective inhibition of BET bromodomains

P. Filippakopoulos, Jun Qi, S. Picaud et al. · Nature · 2010 · 4.2K citations · Full text

Bet Bromodomains, Genetics, Pathogenesis +3

BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc

Jake Delmore, Ghayas C. Issa, Madeleine E. Lemieux et al. · Cell · 2011 · 2.8K citations · Full text

Medicine, Immunology, Therapeutic Efficacy +7

Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity

Yann Echelard, Douglas J. Epstein, Benoit St‐Jacques et al. · Cell · 1993 · 2.2K citations

Molecular Neuroscience, Developmental Biology, Signal Transduction +14