Concepedia

Alternative Immunomodulatory Strategies for Xenotransplantation: CD80/CD86-CTLA4 Pathway-Modified Immature Dendritic Cells Promote Xenograft Survival

Min Tian, Yi Lv, Chao Zhai, Haitao Zhu, Liang Yú, Bo Wang

PLoS ONE · 2013 · 23 citations · 31 references

DOIFull text

Open access

Abstract

These results confirm that selective inhibition of the direct and indirect pathways of T-cell activation by donor CTLA4-IgG4 modified imDCs and receptor CTLA4-Ig is a highly effective strategy to promote survival of xenografts.

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