Xenotransplantation is a research field and biomedical practice involving the transplantation of living cells, tissues, or organs from one species to another, typically from non-human animals into humans. It investigates the biological feasibility and immunological challenges associated with cross-species grafting, aiming to develop therapeutic solutions for conditions such as organ failure while addressing critical concerns like graft rejection and the potential transmission of zoonotic diseases. Its significance lies in its potential to alleviate the severe shortage of human organs and tissues available for transplantation and to provide valuable models for understanding biological processes and disease mechanisms across species barriers.