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Publication | Open Access

Negative Regulation of Myofibroblast Differentiation by PTEN (Phosphatase and Tensin Homolog Deleted on Chromosome 10)

DOIFull Paper Access

198

Citations

44

References

2005

Year

Eric S. White, Rachelle G. Atrasz, Biao Hu, Sem H. Phan, Vuk Stambolic, Tak W. Mak, Cory M. Hogaboam, Kevin R. Flaherty, Fernando J. Martínez, Christopher D. Kontos,
American Journal of Respiratory and Critical Care Medicine

Abstract

The results indicate that in IPF, myofibroblasts have diminished PTEN expression. Inhibition of PTEN in vivo promotes fibrosis, and PTEN inhibits myofibroblast differentiation in vitro.

References

YearCitations

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