Concepedia

Myofibroblast Differentiation

Myofibroblast Differentiation is a cellular differentiation process in which fibroblasts acquire a contractile, matrix-synthesizing phenotype characterized by the expression of α-smooth muscle actin stress fibers and enhanced extracellular matrix remodeling activity, distinguishing it from other fibroblast activation pathways through its mechanosensitive dependence on tissue stiffness and transforming growth factor-β signaling.

2.3K

Publications

182.4K

Citations

13.4K

Authors

2.5K

Institutions

Publications per year

2017–2026

828

Parents

Publications

2.3K

Serial passaging and differentiation of myogenic cells isolated from dystrophic mouse muscle

David Yaffe, Ora Saxel · Nature · 1977 · 2.1K citations

, , +16

Muscle injury activates resident fibro/adipogenic progenitors that facilitate myogenesis

Aaron W. Joe, Lin Yi, Anuradha Natarajan et al. · Nature Cell Biology · 2010 · 1.7K citations · Full text

, , +14

Fate Tracing Reveals the Pericyte and Not Epithelial Origin of Myofibroblasts in Kidney Fibrosis

Benjamin D. Humphreys, Shuei‐Liong Lin, Akio Kobayashi et al. · American Journal Of Pathology · 2009 · 1.4K citations · Full text

, , +16

Origin and function of myofibroblasts in kidney fibrosis

Valerie S. LeBleu, Gangadhar Taduri, Joyce T. O’Connell et al. · Nature Medicine · 2013 · 1.2K citations · Full text

, , +12

Adenovector-mediated gene transfer of active transforming growth factor-beta1 induces prolonged severe fibrosis in rat lung.

Patricia J. Sime, Frank L. Graham, Karl G. Csaky et al. · Journal of Clinical Investigation · 1997 · 1K citations · Full text

, , +17

1–5 of 2.3K

Authors

13.4K

  1. SH
    Sem H. Phan

    University of Michigan, United States

    28 publications · 3.8K citations

    25

    h-index

  2. VJ
    Victor J. Thannickal

    University of Alabama at Birmingham, United States

    24 publications · 4.7K citations

    22

    h-index

  3. BH
    Boris Hinz

    University of Toronto, Canada

    22 publications · 3.8K citations

    20

    h-index

  4. OD
    Oliver Distler

    University Hospital of Zurich, Switzerland

    19 publications · 1.7K citations

    19

    h-index

  5. JH
    Jörg H. W. Distler

    Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany

    19 publications · 1.4K citations

    18

    h-index

1–5 of 13.4K

Institutions

2.5K

  1. University of Michigan

    Ann Arbor, United States

    45 h-index

    325 publications

    37.5K citations

  2. Inserm

    Paris, France

    36 h-index

    352 publications

    27.7K citations

  3. Harvard University

    Cambridge, United States

    36 h-index

    151 publications

    28.3K citations

  4. University of Alabama at Birmingham

    Birmingham, United States

    29 h-index

    189 publications

    28.5K citations

  5. University of Toronto

    Toronto, Canada

    28 h-index

    142 publications

    19.7K citations

  6. Centre National de la Recherche Scientifique

    Paris, France

    26 h-index

    91 publications

    6K citations

  7. Nanjing Medical University

    Nanjing, China

    23 h-index

    192 publications

    8.3K citations

  8. University of Pittsburgh

    Pittsburgh, United States

    23 h-index

    103 publications

    15.2K citations

1–8 of 2.5K

Venues

  1. PubMed

    Repository · 100 publications · 7.5K citations

    47

    h-index

  2. American Journal Of Pathology

    AJP · 49 publications · 7.8K citations

    41

    h-index

  3. Scientific Reports

    74 publications · 3.7K citations

    39

    h-index

  4. Journal of Biological Chemistry

    JBC · 42 publications · 4.9K citations

    38

    h-index

  5. PLoS ONE

    74 publications · 4.1K citations

    38

    h-index

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