Concepedia

mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake

Ömer Yılmaz, Pekka Katajisto, Dudley W. Lamming, Yetiş Gültekin, Khristian E. Bauer-Rowe, Shomit Sengupta, Kıvanç Birsoy, Abdulmetin Dursun, Vedat O. Yilmaz, Martin K. Selig,

Nature · 2012 · 751 citations · 29 references

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29

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

Toshiro Sato, Robert G.J. Vries, Hugo J.G. Snippert et al. · Nature · 2009 · 7.2K citations

, , +14

Identification of stem cells in small intestine and colon by marker gene Lgr5

Nick Barker, Johan H. van Es, Jeroen Kuipers et al. · Nature · 2007 · 5.7K citations

, , +16

Prolonged Rapamycin Treatment Inhibits mTORC2 Assembly and Akt/PKB

Dos D. Sarbassov, Siraj M. Ali, Shomit Sengupta et al. · Molecular Cell · 2006 · 2.6K citations · Full text

, , +6

Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts

Toshiro Sato, Johan H. van Es, Hugo J.G. Snippert et al. · Nature · 2010 · 2.5K citations

, , +15

Intestinal Crypt Homeostasis Results from Neutral Competition between Symmetrically Dividing Lgr5 Stem Cells

Hugo J.G. Snippert, Laurens G. van der Flier, Toshiro Sato et al. · Cell · 2010 · 2K citations · Full text

, , +16