α2-Macroglobulin-Mediated Degradation of Amyloid β1–42: A Mechanism to Enhance Amyloid β Catabolism

Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse

Dale Schenk, Robin Barbour, Whitney Dunn et al. · Nature · 1999 · 3.1K citations

Neurodegenerative Diseases, Alzheimer's Disease, Immunology +7

Isolation and quantification of soluble Alzheimer's β-peptide from biological fluids

Peter Seubert, Carmen Vigo‐Pelfrey, Fred Esch et al. · Nature · 1992 · 1.7K citations

Neurodegenerative Diseases, Alzheimer's Disease, Biochemistry +6

Identification of the major Aβ1–42-degrading catabolic pathway in brain parenchyma: Suppression leads to biochemical and pathological deposition

Nobuhisa Iwata, Satoshi Tsubuki, Yoshie Takaki et al. · Nature Medicine · 2000 · 856 citations

Neurodegenerative Diseases, Synaptic Signaling, Degenerative Pathology +9

Insulin-degrading Enzyme Regulates Extracellular Levels of Amyloid β-Protein by Degradation

Wei Qiao Qiu, Dominic M. Walsh, Zhen Ye et al. · Journal of Biological Chemistry · 1998 · 797 citations · Full text

α-Macroglobulins: structure, shape, and mechanism of proteinase complex formation

Lars Sottrup‐Jensen · Journal of Biological Chemistry · 1989 · 673 citations · Full text

Protein Chemistry, Protein Function, Protein Assembly +4