Concepedia

A Novel Phospholipid Derivative of Indomethacin, DP-155 [Mixture of 1-Steroyl and 1-Palmitoyl-2-{6-[1-(p-chlorobenzoyl)-5-methoxy-2-methyl-3-indolyl acetamido]hexanoyl}-sn-glycero-3-phosophatidyl Choline], Shows Superior Safety and Similar Efficacy in Reducing Brain Amyloid β in an Alzheimer’s Disease Model

Eran Dvir, Jonathan E. Friedman, Jun Young Lee, Jae‐Young Koh, Firas Younis, Shmuel Raz, I. Shapiro, Amnon Hoffman, Arik Dahan, G Rosenberg,

Journal of Pharmacology and Experimental Therapeutics · 2006 · 29 citations · 22 references

DOI

Concepts

References

22

Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice

Karen Hsiao, Paul F. Chapman, Steven P. Nilsen et al. · Science · 1996 · 4.2K citations

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Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

Donalyn Scheuner, Christopher B. Eckman, M. Jensen et al. · Nature Medicine · 1996 · 2.6K citations

, , +16

A subset of NSAIDs lower amyloidogenic Aβ42 independently of cyclooxygenase activity

Sascha Weggen, Jason L. Eriksen, Pritam Das et al. · Nature · 2001 · 1.4K citations

, , +14

Nonsteroidal Antiinflammatory Drugs and the Risk of Alzheimer's Disease

Bas A. in 't Veld, Annemieke Ruitenberg, Albert Hofman et al. · New England Journal of Medicine · 2001 · 1.2K citations · Full text

, , +14

Age-Dependent Changes in Brain, CSF, and Plasma Amyloid β Protein in the Tg2576 Transgenic Mouse Model of Alzheimer's Disease

Takeshi Kawarabayashi, Linda H. Younkin, Takaomi C. Saido et al. · Journal of Neuroscience · 2001 · 1.1K citations · Full text

, , +17