Identification of EZH2 and EZH1 Small Molecule Inhibitors with Selective Impact on Diffuse Large B Cell Lymphoma Cell Growth

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

Yung-Chi Cheng, William H. Prusoff · Biochemical Pharmacology · 1973 · 12.9K citations

Life Sciences, Biochemistry, Chemical Kinetics +14

Protocol for micro-purification, enrichment, pre-fractionation and storage of peptides for proteomics using StageTips

Juri Rappsilber, Matthias Mann, Yasushi Ishihama · Nature Protocols · 2007 · 4.9K citations

Life Sciences, Biochemistry, Biotechnology +10

The polycomb group protein EZH2 is involved in progression of prostate cancer

Sooryanarayana Varambally, Saravana M. Dhanasekaran, Ming Zhou et al. · Nature · 2002 · 2.7K citations · Full text

Life Sciences, Genetics, Molecular Biology +14

Absolute metabolite concentrations and implied enzyme active site occupancy in Escherichia coli

Bryson D. Bennett, Elizabeth Kimball, Melissa Gao et al. · Nature Chemical Biology · 2009 · 1.9K citations · Full text

Life Sciences, Biochemistry, Microbiology +16

EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations

Michael T. McCabe, Heidi M. Ott, Gopinath Ganji et al. · Nature · 2012 · 1.8K citations

Medicine, Molecular Genetics, Oncology +15