Absolute metabolite concentrations and implied enzyme active site occupancy in Escherichia coli

Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing

Yoav Benjamini, Yosef Hochberg · Journal of the Royal Statistical Society Series B (Statistical Methodology) · 1995 · 105.5K citations

Engineering, Statistical Foundation, Powerful Approach +21

Universally Sloppy Parameter Sensitivities in Systems Biology Models

Ryan N. Gutenkunst, Joshua J. Waterfall, Fergal Casey et al. · PLoS Computational Biology · 2007 · 1.3K citations · Full text

Systems Biology Models, Sloppy Parameter Sensitivities, Engineering +13

Escherichia coli K-12 undergoes adaptive evolution to achieve in silico predicted optimal growth

Rafael U. Ibarra, Jeremy S. Edwards, Bernhard Ø. Palsson · Nature · 2002 · 873 citations

Biology, Evolution Strategy, Optimal Growth +4

Thermodynamics-Based Metabolic Flux Analysis

Christopher S. Henry, Linda J. Broadbelt, Vassily Hatzimanikatis · Biophysical Journal · 2006 · 630 citations · Full text

Metabolic Network, Bioenergetics, Physiology +7

Separation and quantitation of water soluble cellular metabolites by hydrophilic interaction chromatography-tandem mass spectrometry

Sunil Bajad, Wenyun Lu, Elizabeth Kimball et al. · Journal of Chromatography A · 2006 · 589 citations

Biochemistry, Gas Chromatography, Medicine +10