Loss of HIF-2α and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice

Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis

Dorit Shweiki, Ahuva Itin, Dov Soffer et al. · Nature · 1992 · 4.6K citations

Life Sciences, Physiology, Tissue Differentiation +11

Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions

Peter Carmeliet, Lieve Moons, Aernout Luttun et al. · Nature Medicine · 2001 · 1.7K citations

Medicine, Pathobiology, Tumor Microenvironment +13

Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells.

Hui-Qiao Tian, Steven L. McKnight, David W. Russell · Genes & Development · 1997 · 1.3K citations · Full text

Life Sciences, Cell Biology, Molecular Biology +16

A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1α regulates the <i>VEGF</i> expression and is potentially involved in lung and vascular development

Masatsugu Ema, Shin-ichiro Taya, Noboru Yokotani et al. · Proceedings of the National Academy of Sciences · 1997 · 1K citations · Full text

Life Sciences, Genetics, Molecular Biology +13

Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration

Bert Oosthuyse, Lieve Moons, Erik Storkebaum et al. · Nature Genetics · 2001 · 1K citations

Life Sciences, Genetics, Molecular Biology +16