Florea Lupu

Extracellular histones are major mediators of death in sepsis

Jun Xu, Xiaomei Zhang, Rosana Pelayo et al. · Nature Medicine · 2009 · 1.5K citations · Full text

Inflammation, Apoptosis, Immunology +6

Targeted Deficiency or Cytosolic Truncation of the VE-cadherin Gene in Mice Impairs VEGF-Mediated Endothelial Survival and Angiogenesis

Peter Carmeliet, Maria Grazia Lampugnani, Lieve Moons et al. · Cell · 1999 · 1.3K citations · Full text

Angiogenesis, Immunology, Endothelial Dysfunction +8

Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration

Bert Oosthuyse, Lieve Moons, Erik Storkebaum et al. · Nature Genetics · 2001 · 1K citations

Neurodegenerative Diseases, Motor Neuron Degeneration, Hypoxia-response Element +10

Inhibition of plasminogen activators or matrix metalloproteinases prevents cardiac rupture but impairs therapeutic angiogenesis and causes cardiac failure

Stéphane Heymans, Aernout Luttun, Dieter Nuyens et al. · Nature Medicine · 1999 · 788 citations

Cardiomyopathy, Heart Failure, Cardiovascular Disease +11

Loss of HIF-2α and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice

Veerle Compernolle, Koen Brusselmans, Till Acker et al. · Nature Medicine · 2002 · 727 citations

Acute Lung Injury, Developmental Biology, Lung Inflammation +12