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Aziridine-2,3-dicarboxylate inhibitors targeting the major cysteine protease of Trypanosoma brucei as lead trypanocidal agents

Radim Vičík, Verena Hoerr, Melanie Glaser, Martina Schultheis, Elizabeth Hansell, James H. McKerrow, Ulrike Holzgrabe, Conor R. Caffrey, Alicia Ponte‐Sucre, Heidrun Moll,

Bioorganic & Medicinal Chemistry Letters · 2006 · 80 citations · 24 references

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24

Cysteine Protease Inhibitors Cure an Experimental <i>Trypanosoma cruzi</i> Infection

Juan C. Engel, Patricia S. Doyle, Ivy Hsieh et al. · The Journal of Experimental Medicine · 1998 · 383 citations · Full text

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The Crystal Structure of Cruzain: A Therapeutic Target for Chagas' Disease

Mary E. McGrath, Ann E. Eakin, Juan C. Engel et al. · Journal of Molecular Biology · 1995 · 268 citations

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Synthesis and Structure−Activity Relationships of Parasiticidal Thiosemicarbazone Cysteine Protease Inhibitors against <i>Plasmodium falciparum</i>, <i>Trypanosoma brucei</i>, and <i>Trypanosoma cruzi</i>

Doron C. Greenbaum, Zachary B. Mackey, Elizabeth Hansell et al. · Journal of Medicinal Chemistry · 2004 · 254 citations · Full text

, , +17

Active site mapping, biochemical properties and subcellular localization of rhodesain, the major cysteine protease of Trypanosoma brucei rhodesiense

Conor R. Caffrey, Elizabeth Hansell, Kimberley D. Lucas et al. · Molecular and Biochemical Parasitology · 2001 · 179 citations

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Discovery of potent thiosemicarbazone inhibitors of rhodesain and cruzain

Naoaki Fujii, Jeremy P. Mallari, Elizabeth Hansell et al. · Bioorganic & Medicinal Chemistry Letters · 2004 · 155 citations · Full text

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