Concepedia

The Cyclooxygenase-2 Inhibitor GW406381X [2-(4-Ethoxyphenyl)-3-[4-(methylsulfonyl)phenyl]-pyrazolo[1,5-b]pyridazine] Is Effective in Animal Models of Neuropathic Pain and Central Sensitization

Sharon Bingham, Paul Beswick, C. Bountra, Terry Brown, Ian B. Campbell, Iain P. Chessell, Nick M. Clayton, S D Collins, Philip T. Davey, Helen Goodland,

Journal of Pharmacology and Experimental Therapeutics · 2005 · 63 citations · 27 references

DOI

Concepts

References

27

A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man

Gary J. Bennett, Yuanyu Xie · Pain · 1988 · 5.4K citations

, , +17

Synthesis and Biological Evaluation of the 1,5-Diarylpyrazole Class of Cyclooxygenase-2 Inhibitors:  Identification of 4-[5-(4-Methylphenyl)-3- (trifluoromethyl)-1<i>H</i>-pyrazol-1-yl]benzenesulfonamide (SC-58635, Celecoxib)

Thomas D. Penning, John J. Talley, Stephen R. Bertenshaw et al. · Journal of Medicinal Chemistry · 1997 · 2K citations · Full text

, , +17

4-[5-Methyl-3-phenylisoxazol-4-yl]- benzenesulfonamide, Valdecoxib:  A Potent and Selective Inhibitor of COX-2

John J. Talley, David Brown, Jeffery S. Carter et al. · Journal of Medicinal Chemistry · 2000 · 643 citations · Full text

, , +8

Biochemical and pharmacological characterization of the cyclooxygenase activity of human blood prostaglandin endoperoxide synthases.

Paola Patrignani, Maria R. Panara, Anita Greco et al. · Journal of Pharmacology and Experimental Therapeutics · 1994 · 518 citations

, , +13

The discovery of rofecoxib, [MK 966, VIOXX®, 4-(4′-methylsulfonylphenyl)-3-phenyl-2(5H)-furanone], an orally active cyclooxygenase-2 inhibitor

Petpiboon Prasit, Z Wang, Christine Brideau et al. · Bioorganic & Medicinal Chemistry Letters · 1999 · 429 citations · Full text

, , +9