Concepedia

The discovery of rofecoxib, [MK 966, VIOXX®, 4-(4′-methylsulfonylphenyl)-3-phenyl-2(5H)-furanone], an orally active cyclooxygenase-2 inhibitor

Petpiboon Prasit, Z Wang, Christine Brideau, Chi‐Chung Chan, S. Charleson, Wanda Cromlish, Diane Ethier, Jilly F. Evans, A W Ford‐Hutchinson, J. Y. GAUTHIER,

Bioorganic & Medicinal Chemistry Letters · 1999 · 429 citations · 15 references

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References

15

Suppression of Intestinal Polyposis in ApcΔ716 Knockout Mice by Inhibition of Cyclooxygenase 2 (COX-2)

Masanobu Oshima, Joseph Dinchuk, Stacia Kargman et al. · Cell · 1996 · 2.4K citations · Full text

, , +16

Cyclooxygenase Regulates Angiogenesis Induced by Colon Cancer Cells

Masahiko Tsujii, Sunao Kawano, Shingo Tsuji et al. · Cell · 1998 · 2.3K citations · Full text

, , +14

Synthesis and Biological Evaluation of the 1,5-Diarylpyrazole Class of Cyclooxygenase-2 Inhibitors:  Identification of 4-[5-(4-Methylphenyl)-3- (trifluoromethyl)-1<i>H</i>-pyrazol-1-yl]benzenesulfonamide (SC-58635, Celecoxib)

Thomas D. Penning, John J. Talley, Stephen R. Bertenshaw et al. · Journal of Medicinal Chemistry · 1997 · 2K citations · Full text

, , +17

Expression of cyclooxygenase-1 and -2 in human colorectal cancer.

Hajime Sano, Yutaka Kawahito, Ronald L. Wilder et al. · PubMed · 1995 · 1.1K citations

, , +10

Risk of Alzheimer's disease and duration of NSAID use

Walter F. Stewart, Claudia H. Kawas, María M. Corrada et al. · Neurology · 1997 · 1.1K citations · Full text

, , +9