Wild-Type and Mutant B-RAF Activate C-RAF through Distinct Mechanisms Involving Heterodimerization

Mutations of the BRAF gene in human cancer

Helen Davies, Graham R. Bignell, Charles Cox et al. · Nature · 2002 · 10.7K citations

Medicine, Genetics, Molecular Genetics +12

Identification of a Novel Inhibitor of Mitogen-activated Protein Kinase Kinase

Margaret Favata, Kurumi Y. Horiuchi, Elizabeth J. Manos et al. · Journal of Biological Chemistry · 1998 · 3K citations · Full text

Life Sciences, Molecular Biology, Pharmacology +13

Mechanism of Activation of the RAF-ERK Signaling Pathway by Oncogenic Mutations of B-RAF

Paul Wan, Mathew J. Garnett, S. Mark Roe et al. · Cell · 2004 · 2.8K citations · Full text

Medicine, Molecular Biology, Oncology +14

Protein kinases 6. The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification.

Steven K. Hanks, Tony Hunter · PubMed · 1995 · 2.5K citations

Life Sciences, Biochemistry, Molecular Biology +17

The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification ¹

Steven K. Hanks, Tony Hunter · The FASEB Journal · 1995 · 2.3K citations

Life Sciences, Biochemistry, Molecular Biology +16