Concepedia

Matrix adhesion and Ras transformation both activate a phosphoinositide 3‐OH kinase and protein kinase B/Akt cellular survival pathway

Asim Khwaja, Pablo Rodriguez‐Viciana, Stefan Wennström, Patricia H. Warne, Julian Downward

The EMBO Journal · 1997 · 1K citations · 66 references

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66

Disruption of epithelial cell-matrix interactions induces apoptosis

SM Frisch, H. Francis · The Journal of Cell Biology · 1994 · 3.3K citations · Full text

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A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002).

Chris J. Vlahos, William F. Matter, K. Y. Hui et al. · Journal of Biological Chemistry · 1994 · 3.3K citations · Full text

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Role of cell shape in growth control

Judah Folkman, Anne Moscona · Nature · 1978 · 2.4K citations

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Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

Boudewijn Burgering, Paul J. Coffer · Nature · 1995 · 2.1K citations

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The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

Thomas Franke, Sung‐Il Yang, Tung O. Chan et al. · Cell · 1995 · 2K citations · Full text

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