Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

Thomas Franke, Sung‐Il Yang, Tung O. Chan et al. · Cell · 1995 · 2K citations · Full text

Akt Proto-oncogene, Signal Transduction, Signaling Pathway +11

Phosphatidylinositol-3-OH kinase direct target of Ras

Pablo Rodriguez‐Viciana, Patricia H. Warne, Ritu Dhand et al. · Nature · 1994 · 1.9K citations

Signal Transduction, Signaling Pathway, Receptor Tyrosine Kinase +5

[11] Phosphopeptide mapping and phosphoamino acid analysis by two-dimensional separation on thin-layer cellulose plates

William J. Boyle, Peter van der Geer, Tony Hunter · Methods in enzymology on CD-ROM/Methods in enzymology · 1991 · 1.5K citations

Biochemistry, Separation Science, Phosphoamino Acid Analysis +8

Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses

Alexandre Arcaro, Matthias P. Wymann · Biochemical Journal · 1993 · 1.1K citations · Full text

Immunology, Ptdinsp3 Production, Inflammation +17

Purification of a RAS-responsive adenylyl cyclase complex from Saccharomyces cerevisiae by use of an epitope addition method.

Jeffrey Field, Jun‐ichi Nikawa, Daniel Broek et al. · Molecular and Cellular Biology · 1988 · 960 citations · Full text

Engineering, Molecular Biology, Protein Purification +16