Matthias P. Wymann

Central Role for G Protein-Coupled Phosphoinositide 3-Kinase γ in Inflammation

Emilio Hirsch, Vladimir L. Katanaev, Cecília Garlanda et al. · Science · 2000 · 1.2K citations

Structural Determinants of Phosphoinositide 3-Kinase Inhibition by Wortmannin, LY294002, Quercetin, Myricetin, and Staurosporine

Edward H. Walker, Michael E. Pacold, Olga Perišić et al. · Molecular Cell · 2000 · 1.2K citations · Full text

Molecular Pharmacology, Signal Transduction, Biochemistry +11

Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses

Alexandre Arcaro, Matthias P. Wymann · Biochemical Journal · 1993 · 1.1K citations · Full text

Immunology, Ptdinsp3 Production, Inflammation +17

Blockade of PI3Kγ suppresses joint inflammation and damage in mouse models of rheumatoid arthritis

Montserrat Camps, Thomas Rückle, Hong Ji et al. · Nature Medicine · 2005 · 742 citations

Immunology, Immune Regulation, Cell Death +16

Wortmannin Inactivates Phosphoinositide 3-Kinase by Covalent Modification of Lys-802, a Residue Involved in the Phosphate Transfer Reaction

Matthias P. Wymann, Ginette Bulgarelli-Leva, Marketa Zvelebil et al. · Molecular and Cellular Biology · 1996 · 677 citations · Full text

Signal Transduction, Biochemistry, Natural Sciences +13