Universal chromogenic substrates for lipases and esterases

Rapid evolution of a protein in vitro by DNA shuffling

Willem P.C. Stemmer · Nature · 1994 · 1.9K citations

Life Sciences, Genetics, Molecular Biology +10

Introduction to Multivariate Analysis

Jack C. Lee, C. Chatfield, Alexander J. Collins · Technometrics · 1983 · 1.8K citations

Natural Sciences, Data Science, Econometrics +14

DNA shuffling by random fragmentation and reassembly: in vitro recombination for molecular evolution.

Willem PC Stemmer · Proceedings of the National Academy of Sciences · 1994 · 1.3K citations

Life Sciences, Biology, Molecular Biology +15

Combinatorial and Evolution-Based Methods in the Creation of Enantioselective Catalysts

Manfred T. Reetz · Angewandte Chemie International Edition · 2001 · 590 citations

Natural Sciences, Chemical Engineering, Chemistry +14

Directed evolution of subtilisin E in <i>Bacillus subtilis</i> to enhance total activity in aqueous dimethylformamide

Le-Xing You, Frances H. Arnold · Protein Engineering Design and Selection · 1996 · 274 citations

Life Sciences, Biochemistry, Microbiology +17