Concepedia

β-Site Amyloid Precursor Protein Cleaving Enzyme 1 Increases Amyloid Deposition in Brain Parenchyma but Reduces Cerebrovascular Amyloid Angiopathy in Aging BACE × APP[V717I] Double-Transgenic Mice

Michael Willem, Ilse Dewachter, Neil Smyth, Tom Van Dooren, Peter Borghgraef, Christian Haass, Fred Van Leuven

American Journal Of Pathology · 2004 · 55 citations · 39 references

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39

β-Secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACE

Robert Vassar, Brian D. Bennett, Safura Babu‐Khan et al. · Science · 1999 · 3.8K citations · Full text

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Membrane-anchored aspartyl protease with Alzheimer's disease β-secretase activity

Riqiang Yan, Michael J. Bienkowski, Mary E. Shuck et al. · Nature · 1999 · 1.4K citations

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Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

Ishrut Hussain, David J. Powell, David Howlett et al. · Molecular and Cellular Neuroscience · 1999 · 1.1K citations

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BACE1 is the major β-secretase for generation of Aβ peptides by neurons

Huaibin Cai, Yanshu Wang, Diane B. McCarthy et al. · Nature Neuroscience · 2001 · 1.1K citations

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Mice deficient in BACE1, the Alzheimer's β-secretase, have normal phenotype and abolished β-amyloid generation

Yi Luo, Brad Bolon, Steve Kahn et al. · Nature Neuroscience · 2001 · 994 citations

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