Concepedia

Increased sensitivity to anticancer drugs and decreased inflammatory response in mice lacking the multidrug resistance-associated protein

Jan Wijnholds, Raymond Evers, Manuel R. van Leusden, Carla A.A.M. Mol, Guido J.R. Zaman, Ulrich Mayer, Jos H. Beijnen, Martin van der Valk, Paul Krimpenfort, Piet Borst

Nature Medicine · 1997 · 438 citations · 24 references

DOI

Concepts

References

24

Overexpression of a Transporter Gene in a Multidrug-Resistant Human Lung Cancer Cell Line

Susan P.C. Cole, Gabu Bhardwaj, James H. Gerlach et al. · Science · 1992 · 3.1K citations

, , +16

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

Alfred H. Schinkel, Jasper Smit, Olaf van Tellingen et al. · Cell · 1994 · 2.3K citations

, , +14

Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins

Alfred H. Schinkel, Ulrich Mayer, Els Wagenaar et al. · Proceedings of the National Academy of Sciences · 1997 · 941 citations

, , +11

The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates.

Inka Leier, Gabriele Jedlitschky, Ulrike Buchholz et al. · Journal of Biological Chemistry · 1994 · 856 citations · Full text

, , +14

Congenital Jaundice in Rats with a Mutation in a Multidrug Resistance-Associated Protein Gene

Coen C. Paulusma, Piter J. Bosma, Guido J.R. Zaman et al. · Science · 1996 · 832 citations

, , +17