Martin van der Valk

Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer

Jos Jonkers, Ralph Meuwissen, Hanneke van der Gulden et al. · Nature Genetics · 2001 · 1.1K citations

Tumor Biology, Breast Oncology, Oncology +9

Requirement for a functional Rb-1 gene in murine development

Alan R. Clarke, Els Robanus Maandag, M van Roon et al. · Nature · 1992 · 1K citations

Transcriptional Regulation, Developmental Biology, Functional Rb-1 Gene +6

Posterior transformation, neurological abnormalities, and severe hematopoietic defects in mice with a targeted deletion of the bmi-1 proto-oncogene.

N M van der Lugt, Jos Domen, Koert Linders et al. · Genes & Development · 1994 · 778 citations · Full text

Bmi-1 Gene, B-cell Lymphomagenesis, Genetics +19

Potent and specific inhibition of the breast cancer resistance protein multidrug transporter in vitro and in mouse intestine by a novel analogue of fumitremorgin C.

John Allen, Arnold van Loevezijn, Jeany M Lakhai et al. · PubMed · 2002 · 687 citations

Bcrp Activity, Pharmacotherapy, Other Ftc Analogues +17

Increased sensitivity to anticancer drugs and decreased inflammatory response in mice lacking the multidrug resistance-associated protein

Jan Wijnholds, Raymond Evers, Manuel R. van Leusden et al. · Nature Medicine · 1997 · 437 citations

Inflammation, Anti-inflammatory, Medicine +9