Metabolism of prostaglandin endoperoxide in animal tissues

An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation

Salvador Moncada, Ryszard J. Gryglewski, S Bunting et al. · Nature · 1976 · 3.6K citations

Medicine, Biochemistry, Pharmacology +16

Arterial walls generate from prostaglandin endoperoxides a substance (prostaglandin X) which relaxes strips of mesenteric and coeliac arteries and inhibits platelet aggregation

Stuart Bunting, Salvador Moncada, John R. Vane et al. · Prostaglandins · 1976 · 955 citations

Medicine, Physiology, Signal Transduction +11

Release of Additional Factors in Anaphylaxis and its Antagonism by Anti-inflammatory Drugs

Priscilla J. Piper, John R. Vane · Nature · 1969 · 887 citations

Life Sciences, Immunology, Pharmacology +14

Isolation and properties of intermediates in prostaglandin biosynthesis

D.H. Nugteren, E. Hazelhof · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · 1973 · 795 citations

Life Sciences, Biochemistry, Molecular Biology +8

The chemical structure of prostaglandin X (prostacyclin)

Roy A. Johnson, Douglas R. Morton, John H. Kinner et al. · Prostaglandins · 1976 · 730 citations

Natural Sciences, Chemistry, Pharmacology +10