Concepedia

Design, synthesis, in silico and in vitro screening of 1,2,4-thiadiazole analogues as non-peptide inhibitors of beta-secretase

Archana S. Gurjar, Vincenza Andrisano, Angela De Simone, Vinay S. Velingkar

Bioorganic Chemistry · 2014 · 41 citations · 15 references

DOI

Concepts

References

15

Structure of the Protease Domain of Memapsin 2 (β-Secretase) Complexed with Inhibitor

Hong Lin, Gerald Koelsch, Xinli Lin et al. · Science · 2000 · 706 citations

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Crystal Structure of Memapsin 2 (β-Secretase) in Complex with an Inhibitor OM00-3

Hong Lin, Robert T. Turner, Gerald Koelsch et al. · Biochemistry · 2002 · 190 citations

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Subsite Specificity of Memapsin 2 (β-Secretase):  Implications for Inhibitor Design

Robert T. Turner, Gerald Koelsch, Lin Hong et al. · Biochemistry · 2001 · 184 citations

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Discovery of AZD3839, a Potent and Selective BACE1 Inhibitor Clinical Candidate for the Treatment of Alzheimer Disease

Fredrik Jeppsson, Susanna Eketjäll, Juliette Janson et al. · Journal of Biological Chemistry · 2012 · 138 citations · Full text

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Design and Synthesis of 5,5′-Disubstituted Aminohydantoins as Potent and Selective Human β-Secretase (BACE1) Inhibitors

Michael S. Malamas, Jim Erdei, Iwan Gunawan et al. · Journal of Medicinal Chemistry · 2009 · 133 citations · Full text

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