Angela De Simone

Synthesis and Multitarget Biological Profiling of a Novel Family of Rhein Derivatives As Disease-Modifying Anti-Alzheimer Agents

Elisabet Viayna, Irene Sola, Manuela Bartolini et al. · Journal of Medicinal Chemistry · 2014 · 148 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17

Novel Tacrine–Benzofuran Hybrids as Potent Multitarget-Directed Ligands for the Treatment of Alzheimer’s Disease: Design, Synthesis, Biological Evaluation, and X-ray Crystallography

Xiaoming Zha, Doriano Lamba, Lili Zhang et al. · Journal of Medicinal Chemistry · 2015 · 129 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Multitarget Drug Discovery for Alzheimer's Disease: Triazinones as BACE‐1 and GSK‐3β Inhibitors

Federica Prati, Angela De Simone, Paola Bisignano et al. · Angewandte Chemie International Edition · 2014 · 123 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17

Versatility of the Curcumin Scaffold: Discovery of Potent and Balanced Dual BACE-1 and GSK-3β Inhibitors

Rita Maria Concetta Di Martino, Angela De Simone, Vincenza Andrisano et al. · Journal of Medicinal Chemistry · 2015 · 121 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Amyloid β-Peptide 25–35 Self-Assembly and Its Inhibition: A Model Undecapeptide System to Gain Atomistic and Secondary Structure Details of the Alzheimer’s Disease Process and Treatment

Marina Naldi, Jessica Fiori, Marco Pistolozzi et al. · ACS Chemical Neuroscience · 2012 · 118 citations

Life Sciences, Biochemistry, Biophysics +17