Novel Donepezil-Based Inhibitors of Acetyl- and Butyrylcholinesterase and Acetylcholinesterase-Induced β-Amyloid Aggregation

Pelayo Camps, X. Formosa, Carles Galdeano, +14

Journal of Medicinal Chemistry

Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition

Susan Wyllie, Stephen Brand, Michael G. Thomas, +46

Proceedings of the National Academy of Sciences

Synthesis and Multitarget Biological Profiling of a Novel Family of Rhein Derivatives As Disease-Modifying Anti-Alzheimer Agents

Elisabet Viayna, Irene Sola, Manuela Bartolini, +11

Journal of Medicinal Chemistry

Rhein DerivativesMultitarget Biological ProfilingSynaptic TransmissionNovel FamilyChemical Derivative +16

Huprine–Tacrine Heterodimers as Anti-Amyloidogenic Compounds of Potential Interest against Alzheimer’s and Prion Diseases

Carles Galdeano, Elisabet Viayna, Irene Sola, +15

Journal of Medicinal Chemistry

Peptide SciencePrion PeptideHuprine–tacrine HeterodimersMolecular PharmacologyMedicinal Chemistry +17

Discovery of a Potent Dual Inhibitor of Acetylcholinesterase and Butyrylcholinesterase with Antioxidant Activity that Alleviates Alzheimer-like Pathology in Old APP/PS1 Mice

Elisabet Viayna, Nicolas Coquelle, Monika Cieslikiewicz‐Bouet, +23

Journal of Medicinal Chemistry

Tacrine-based dual binding site acetylcholinesterase inhibitors as potential disease-modifying anti-Alzheimer drug candidates

Pelayo Camps, X. Formosa, Carles Galdeano, +15

Chemico-Biological Interactions

Neurodegenerative DiseasesDrug TargetAlzheimer's DiseaseMedicineDementia +8

Multicomponent reaction-based synthesis and biological evaluation of tricyclic heterofused quinolines with multi-trypanosomatid activity

Ornella Di Pietro, Esther Vicente‐García, Martin C. Taylor, +12

European Journal of Medicinal Chemistry

Novel Huprine Derivatives with Inhibitory Activity toward β‐Amyloid Aggregation and Formation as Disease‐Modifying Anti‐Alzheimer Drug Candidates

Elisabet Viayna, Tània Gómez, Carles Galdeano, +16

ChemMedChem

Difluoromethyl ketones: Potent inhibitors of wild type and carbamate-insensitive G119S mutant Anopheles gambiae acetylcholinesterase

Eugene Camerino, Dawn M. Wong, Fan Tong, +9

Bioorganic & Medicinal Chemistry Letters

BiochemistryWild TypeMedicineNatural SciencesDifluoromethyl Ketones +7

1,2,3,4-Tetrahydrobenzo[h][1,6]naphthyridines as a new family of potent peripheral-to-midgorge-site inhibitors of acetylcholinesterase: Synthesis, pharmacological evaluation and mechanistic studies

Ornella Di Pietro, Elisabet Viayna, Esther Vicente‐García, +9

European Journal of Medicinal Chemistry

Medicinal ChemistryNew FamilyMechanistic StudiesBiochemistryPotent Peripheral-to-midgorge-site Inhibitors +7