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Synthesis and SAR studies of bicyclic amine series GPR119 agonists

Masao Sakairi, Masakazu Kogami, Masafumi Torii, Hiroyo Kataoka, Hiroki Fujieda, Mitsuhiro Makino, Daisuke Kataoka, Ryuji Okamoto, Toshiyuki Miyazawa, Morio Okabe,

Bioorganic & Medicinal Chemistry Letters · 2012 · 25 citations · 12 references

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12

A Role for Intestinal Endocrine Cell-Expressed G Protein-Coupled Receptor 119 in Glycemic Control by Enhancing Glucagon-Like Peptide-1 and Glucose-Dependent Insulinotropic Peptide Release

Zhi‐Liang Chu, Christopher J. Carroll, Jean Alfonso et al. · Endocrinology · 2008 · 380 citations

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Lysophosphatidylcholine enhances glucose-dependent insulin secretion via an orphan G-protein-coupled receptor

Takatoshi Soga, Takahide Ohishi, Tetsuo Matsui et al. · Biochemical and Biophysical Research Communications · 2004 · 374 citations

, , +14

Discovery of the First Potent and Orally Efficacious Agonist of the Orphan G-Protein Coupled Receptor 119

Graeme Semple, Beatriz Fioravanti, Imelda Calderon et al. · Journal of Medicinal Chemistry · 2008 · 142 citations · Full text

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Expression and distribution of Gpr119 in the pancreatic islets of mice and rats: Predominant localization in pancreatic polypeptide-secreting PP-cells

Yukiko Sakamoto, Hiroshi Inoue, Shuhei Kawakami et al. · Biochemical and Biophysical Research Communications · 2006 · 99 citations

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Agonists at GPR119 mediate secretion of GLP‐1 from mouse enteroendocrine cells through glucose‐independent pathways

Wang Cf, M. Jerry Wright, Shiyao Xu et al. · British Journal of Pharmacology · 2011 · 84 citations · Full text

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