Unstable metabolites of arachidonic acid aspirin and the formation of the haemostatic plug

An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation

Salvador Moncada, Ryszard J. Gryglewski, S Bunting et al. · Nature · 1976 · 3.6K citations

Medicine, Biochemistry, Pharmacology +16

Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides.

Mats Hámberg, Jan Olof Svensson, B Samuelsson · Proceedings of the National Academy of Sciences · 1975 · 3.1K citations · Full text

Medicine, Pharmacology, Biochemical Pharmacology +14

HUMAN ARTERIAL AND VENOUS TISSUES GENERATE PROSTACYCLIN (PROSTAGLANDIN X), A POTENT INHIBITOR OF PLATELET AGGREGATION

Salvador Moncada, E.A. Higgs, John R. Vane · The Lancet · 1977 · 887 citations

Medicine, Hematology, Pharmacology +13

A lipid peroxide inhibits the enzyme in blood vessel microsomes that generates from prostaglandin endoperoxides the substance (prostaglandin X) which prevents platelet aggregation

Salvador Moncada, Ryszard J. Gryglewski, Stuart Bunting et al. · Prostaglandins · 1976 · 605 citations

Life Sciences, Biochemistry, Physiology +16

The Bleeding Time as a Screening Test for Evaluation of Platelet Function

Laurence A. Harker, Sherrill J. Slichter · New England Journal of Medicine · 1972 · 570 citations

Medicine, Hematology, Chemotherapy +16