Engineered gene over-expression as a method of drug target identification

Growth of myxamoebae of the cellular slime mould <i>Dictyostelium discoideum</i> in axenic culture

Donald J. Watts, John Ashworth · Biochemical Journal · 1970 · 1.1K citations · Full text

Biology, Mycelial Interaction, Unicellular Organism +12

Gene amplification, drug resistance, and cancer.

Robert Schimke · PubMed · 1984 · 284 citations

Gene Amplification, Genetics, Molecular Genetics +17

Nitrogen-Containing Bisphosphonate Mechanism of Action

Alfred A. Reszka · Mini-Reviews in Medicinal Chemistry · 2012 · 180 citations

Sclerostin, Bioorganic Chemistry, N-bps Results +18

Dynacortin, a Genetic Link between Equatorial Contractility and Global Shape Control Discovered by Library Complementation of a <i>Dictyostelium discoideum</i> Cytokinesis Mutant

Douglas N. Robinson, James A. Spudich · The Journal of Cell Biology · 2000 · 102 citations · Full text

Genetics, Cytoskeleton, Molecular Genetics +20

The Intracellular Target for the Antiresorptive Aminobisphosphonate Drugs in <i>Dictyostelium discoideum</i> Is the Enzyme Farnesyl Diphosphate Synthase

Joanna E. Grove, R. J. Brown, Donald J. Watts · Journal of Bone and Mineral Research · 2000 · 73 citations