Concepedia

Gene amplification, drug resistance, and cancer.

Robert Schimke

PubMed · 1984 · 284 citations · 45 references

Concepts

Abstract

Amplification du gene de la dihydrofolate reductase et resistance au methotrexate dans des cellules mammaliennes en culture. Amplification des genes: frequence mecanisme, resistance clinique aux substances chimiotherapiques, oncogenese

References

45

Human c-myc onc gene is located on the region of chromosome 8 that is translocated in Burkitt lymphoma cells.

Riccardo Dalla‐Favera, Marco Bregni, J Erikson et al. · Proceedings of the National Academy of Sciences · 1982 · 1.8K citations

, , +16

Activation of a cellular onc gene by promoter insertion in ALV-induced lymphoid leukosis

W S Hayward, Benjamin G. Neel, Susan M. Astrin · Nature · 1981 · 1.6K citations

, , +10

Selective multiplication of dihydrofolate reductase genes in methotrexate-resistant variants of cultured murine cells.

F W Alt, Rodney E. Kellems, Joseph R. Bertino et al. · Journal of Biological Chemistry · 1978 · 979 citations · Full text

, , +8

Homogeneously staining chromosomal regions contain amplified copies of an abundantly expressed cellular oncogene (c-myc) in malignant neuroendocrine cells from a human colon carcinoma.

Kari Alitalo, M. Schwab, Ching‐Shwun Lin et al. · Proceedings of the National Academy of Sciences · 1983 · 764 citations · Full text

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THE EFFECTS OF UNEQUAL CROSSING OVER AT THE BAR LOCUS IN DROSOPHILA

A. H. Sturtevant · Genetics · 1925 · 431 citations · Full text

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