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A role for calpain-dependent cleavage of TDP-43 in amyotrophic lateral sclerosis pathology

Takenari Yamashita, Takuto Hideyama, Kosuke Hachiga, Sayaka Teramoto, Jiro Takano, Nobuhisa Iwata, Takaomi C. Saido, Shin Kwak

Nature Communications · 2012 · 174 citations · 50 references

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50

Ubiquitinated TDP-43 in Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis

Manuela Neumann, Deepak M. Sampathu, Linda K. Kwong et al. · Science · 2006 · 6.6K citations

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TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

Tetsuaki Arai, Masato Hasegawa, Haruhiko Akiyama et al. · Biochemical and Biophysical Research Communications · 2006 · 2.8K citations

, , +11

Neurotoxicity induces cleavage of p35 to p25 by calpain

Ming‐Sum Lee, Young T. Kwon, Mingwei Li et al. · Nature · 2000 · 1.1K citations

, , +9

Point mutation in an AMPA receptor gene rescues lethality in mice deficient in the RNA-editing enzyme ADAR2

Miyoko Higuchi, Stefan Maas, Frank N. Single et al. · Nature · 2000 · 989 citations

, , +14

Pathological TDP‐43 distinguishes sporadic amyotrophic lateral sclerosis from amyotrophic lateral sclerosis with <i>SOD1</i> mutations

Ian R. Mackenzie, Eileen H. Bigio, Paul G. Ince et al. · Annals of Neurology · 2007 · 988 citations · Full text

, , +17