A role for calpain-dependent cleavage of TDP-43 in amyotrophic lateral sclerosis pathology

Takenari Yamashita, Takuto Hideyama, Kosuke Hachiga, +5

Nature Communications

Neurodegenerative DiseasesAmyotrophic Lateral SclerosisSignal TransductionNeurochemical BiomarkersProtein Misfolding +7

Induced Loss of ADAR2 Engenders Slow Death of Motor Neurons from Q/R Site-Unedited GluR2

Takuto Hideyama, Takenari Yamashita, Takeshi Suzuki, +6

Journal of Neuroscience

TDP-43 pathology in sporadic ALS occurs in motor neurons lacking the RNA editing enzyme ADAR2

Hitoshi Aizawa, Jun Sawada, Takuto Hideyama, +6

Acta Neuropathologica

Neurodegenerative DiseasesAmyotrophic Lateral SclerosisSporadic AlsMotor NeuronsMedicine +11

Underediting of GluR2 mRNA, a neuronal death inducing molecular change in sporadic ALS, does not occur in motor neurons in ALS1 or SBMA

Yukio Kawahara, Hui Sun, Kyoko Ito, +5

Neuroscience Research

Amyotrophic Lateral SclerosisSporadic AlsMotor NeuronsCell DeathDegenerative Disease +7

Determination of editors at the novel A-to-I editing positions

Yoshinori Nishimoto, Takenari Yamashita, Takuto Hideyama, +3

Neuroscience Research

Scholarly CommunicationWriter IdentificationDirector’s WorkScreenplay

Deficient RNA-editing enzyme ADAR2 in an amyotrophic lateral sclerosis patient with a FUSP525L mutation

Hitoshi Aizawa, Takuto Hideyama, Takenari Yamashita, +4

Journal of Clinical Neuroscience

Neurodegenerative DiseasesAmyotrophic Lateral SclerosisMedicineGeneticsFusp525l Mutation +4

Co-Occurrence of TDP-43 Mislocalization with Reduced Activity of an RNA Editing Enzyme, ADAR2, in Aged Mouse Motor Neurons

Takuto Hideyama, Sayaka Teramoto, Kosuke Hachiga, +2

PLoS ONE

Amyotrophic Lateral SclerosisMolecular NeuroscienceElderly PatientsMotor NeuronsReduced Activity +12

A Positron Emission Tomography Study on the Role of Nigral Lesions in Parkinsonism in Patients With Amyotrophic Lateral Sclerosis

Takuto Hideyama, Toshimitsu Momose, Jun Shimizu, +2

Archives of Neurology

The abnormal processing of TDP-43 is not an upstream event of reduced ADAR2 activity in ALS motor neurons

Takenari Yamashita, Takuto Hideyama, Sayaka Teramoto, +1

Neuroscience Research

Neurodegenerative DiseasesAmyotrophic Lateral SclerosisAbnormal ProcessingNeurophysiologyPhysiology +8

RNA editing of the Q/R site of GluA2 in different cultured cell lines that constitutively express different levels of RNA editing enzyme ADAR2

Takenari Yamashita, Chieko Tadami, Yoshinori Nishimoto, +4

Neuroscience Research

Rna ProcessingQ/r SiteNatural SciencesProtein BiosynthesisMolecular Biology +7