RNA editing and death of motor neurons

Yukio Kawahara, Kyoko Ito, Hui Sun, +3

Nature

Neurodegenerative DiseasesMolecular NeuroscienceMotor NeuronsNeuroscienceMedicine +4

Reduction of GluR2 RNA editing, a molecular change that increases calcium influx through AMPA receptors, selective in the spinal ventral gray of patients with amyotrophic lateral sclerosis

Hiroshi Takuma, Shin Kwak, Toshihiro Yoshizawa, +1

Annals of Neurology

Neurodegenerative DiseasesCalcium InfluxAmyotrophic Lateral SclerosisNeurophysiologyNeurological Disorder +11

A role for calpain-dependent cleavage of TDP-43 in amyotrophic lateral sclerosis pathology

Takenari Yamashita, Takuto Hideyama, Kosuke Hachiga, +5

Nature Communications

Neurodegenerative DiseasesAmyotrophic Lateral SclerosisSignal TransductionNeurochemical BiomarkersProtein Misfolding +7

Induced Loss of ADAR2 Engenders Slow Death of Motor Neurons from Q/R Site-Unedited GluR2

Takuto Hideyama, Takenari Yamashita, Takeshi Suzuki, +6

Journal of Neuroscience

Human spinal motoneurons express low relative abundance of GluR2 mRNA: an implication for excitotoxicity in ALS

Yukio Kawahara, Shin Kwak, Hui Sun, +5

Journal of Neurochemistry

Low Relative AbundanceAmpa Receptor SubunitsNeurotransmissionSocial SciencesNeurology +14

TDP-43 pathology in sporadic ALS occurs in motor neurons lacking the RNA editing enzyme ADAR2

Hitoshi Aizawa, Jun Sawada, Takuto Hideyama, +6

Acta Neuropathologica

Neurodegenerative DiseasesAmyotrophic Lateral SclerosisSporadic AlsMotor NeuronsMedicine +11

Correspondence

Soichi Nagao, Shin Kwak, Ichiro Kanazawa

Neuroscience

Low editing efficiency of GluR2 mRNA is associated with a low relative abundance of ADAR2 mRNA in white matter of normal human brain

Yukio Kawahara, Kyoko Ito, Hui Sun, +2

European Journal of Neuroscience

Systems BiologyG Protein-coupled ReceptorNatural SciencesWhite MatterNeurotransmitter +9

The AMPA receptor antagonist perampanel robustly rescues amyotrophic lateral sclerosis (ALS) pathology in sporadic ALS model mice

Megumi Akamatsu, Takenari Yamashita, Naoki Hirose, +2

Scientific Reports

Rescue of amyotrophic lateral sclerosis phenotype in a mouse model by intravenous <scp>AAV</scp> 9‐ <scp> <i>ADAR</i> </scp> <i>2</i> delivery to motor neurons

Takenari Yamashita, Hui Chai, Sayaka Teramoto, +4

EMBO Molecular Medicine