A Diversity‐Oriented, Microwave‐Assisted Synthesis of 4‐oxo and 4‐chloropyrido[2,3‐<i>d</i>]pyrimidin‐7(8<i>H</i>)‐ones

Abstract

Abstract A microwave‐assisted protocol for the synthesis of 4‐oxo and 4‐chloropyrido[2,3‐ d ]pyrimidin‐7(8 H )‐ones, 13 and 9 respectively, bearing a carbon substituent at C2 and a chlorine atom at C4 is reported. The introduction of a wide range of substituents at C2 renders this methodology easily amenable to combinatorial chemistry applications. Two examples of further derivatization of compounds 9 , substitution by amine and Suzuki coupling, under microwave irradiation are also described.