The Discovery of Pyrano[3,4‐<i>b</i>]indole‐Based Allosteric Inhibitors of HCV NS5B Polymerase with In Vivo Activity

Abstract

Antiviral agents against hepatitis C: The discovery and synthesis of pyrano[3,4-b]indole based inhibitors of HCV NS5B polymerase is described. These compounds effectively inhibit HCV NS5B polymerase and display potent activities in a subgenomic HCV replicon assay. In particular, a sec-butyl-analogue of HCV-371 demonstrates in vivo antiviral activity in the chimeric mouse model of HCV infection. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2452/2008/z800168_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.