The Discovery of Pyrano[3,4‐<i>b</i>]indole‐Based Allosteric Inhibitors of HCV NS5B Polymerase with In Vivo Activity

Abstract

Antiviral agents against hepatitis C: The discovery and synthesis of pyrano[3,4-b]indole based inhibitors of HCV NS5B polymerase is described. These compounds effectively inhibit HCV NS5B polymerase and display potent activities in a subgenomic HCV replicon assay. In particular, a sec-butyl-analogue of HCV-371 demonstrates in vivo antiviral activity in the chimeric mouse model of HCV infection.