MiR-28 regulates Nrf2 expression through a Keap1-independent mechanism

Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

Albena T. Dinkova‐Kostova, W. David Holtzclaw, Robert N. Cole et al. · Proceedings of the National Academy of Sciences · 2002 · 1.9K citations · Full text

Aldo-keto Reductase, Molecular Biology, Thiol Addition +19

Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in <i>nrf2</i> transcription factor-deficient mice

Minerva Ramos‐Gómez, Mi-Kyoung Kwak, Patrick M. Dolan et al. · Proceedings of the National Academy of Sciences · 2001 · 1.1K citations · Full text

Pathology, Cancer Biology, Redox Biology +21

Dysfunctional KEAP1–NRF2 Interaction in Non-Small-Cell Lung Cancer

Anju Singh, Vikas Misra, Rajesh K. Thimmulappa et al. · PLoS Medicine · 2006 · 1K citations · Full text

MicroRNAs accurately identify cancer tissue origin

Nitzan Rosenfeld, Ranit Aharonov, Eti Meiri et al. · Nature Biotechnology · 2008 · 982 citations

Cancer Tissue Origin, Medicine, Small Rna +6

Protection against electrophile and oxidant stress by induction of the phase 2 response: Fate of cysteines of the Keap1 sensor modified by inducers

Nobunao Wakabayashi, Albena T. Dinkova‐Kostova, W. David Holtzclaw et al. · Proceedings of the National Academy of Sciences · 2004 · 959 citations · Full text

Molecular Biology, Redox Biology, Oxidant Stress +19