Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

Albena T. Dinkova‐Kostova, W. David Holtzclaw, Robert N. Cole, +5

Proceedings of the National Academy of Sciences

Aldo-keto ReductaseMolecular BiologyThiol AdditionRedox BiologyOxidative Stress +17

Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in <i>nrf2</i> transcription factor-deficient mice

Minerva Ramos‐Gómez, Mi-Kyoung Kwak, Patrick M. Dolan, +4

Proceedings of the National Academy of Sciences

PathologyCancer BiologyRedox BiologyOxidative StressTranscriptional Regulation +19

Dysfunctional KEAP1–NRF2 Interaction in Non-Small-Cell Lung Cancer

Anju Singh, Vikas Misra, Rajesh K. Thimmulappa, +9

PLoS Medicine

MicroRNAs accurately identify cancer tissue origin

Nitzan Rosenfeld, Ranit Aharonov, Eti Meiri, +30

Nature Biotechnology

Cancer Tissue OriginMedicineSmall RnaMicrorna DetectionMolecular Diagnostics +4

Protection against electrophile and oxidant stress by induction of the phase 2 response: Fate of cysteines of the Keap1 sensor modified by inducers

Nobunao Wakabayashi, Albena T. Dinkova‐Kostova, W. David Holtzclaw, +5

Proceedings of the National Academy of Sciences

Molecular BiologyRedox BiologyOxidant StressOxidative StressSignaling Pathway +17

BTB Protein Keap1 Targets Antioxidant Transcription Factor Nrf2 for Ubiquitination by the Cullin 3-Roc1 Ligase

Manabu Furukawa, Yue Xiong

Molecular and Cellular Biology

Molecular BiologyRedox BiologyOxidative StressSignaling PathwayAutophagy +15

The Cap'n'Collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification and glutathione biosynthetic enzymes.

Michael McMahon, Ken Itoh, Masayuki Yamamoto, +6

PubMed

Chemoprevention StrategyBiochemistryInducible ExpressionMedicineNatural Sciences +13

Loss of Keap1 Function Activates Nrf2 and Provides Advantages for Lung Cancer Cell Growth

Tsutomu Ohta, Kumiko Iijima, Mamiko Miyamoto, +10

Cancer Research

Micro-RNA profiling in kidney and bladder cancers

Fedra Gottardo, Chang Gong Liu, Manuela Ferracin, +10

Urologic Oncology Seminars and Original Investigations

UrologyGenitourinary CancerSmall RnaMicrorna DetectionMolecular Diagnostics +1

Enhanced Expression of the Transcription Factor Nrf2 by Cancer Chemopreventive Agents: Role of Antioxidant Response Element-Like Sequences in the <i>nrf2</i> Promoter

Mi-Kyoung Kwak, Ken Itoh, Masayuki Yamamoto, +1

Molecular and Cellular Biology

Chemoprevention StrategyLipid PeroxidationCell DeathRedox BiologyOxidative Stress +17