Concepedia

A catch-and-release strategy for the combinatorial synthesis of 4-acylamino-1,3-thiazoles as potential CDK5 inhibitors

Scott D. Larsen, Carl F Stachew, Paula M. Clare, Jerry W. Cubbage, Karen L. Leach

Bioorganic & Medicinal Chemistry Letters · 2003 · 26 citations · 7 references

DOIFull text

Open access

Concepts

References

7

General atomic and molecular electronic structure system

Michael W. Schmidt, Kim K. Baldridge, Jerry A. Boatz et al. · Journal of Computational Chemistry · 1993 · 20.2K citations

, , +17

Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

Gentry N. Patrick, Lawrence Zukerberg, Margareta Nikolić et al. · Nature · 1999 · 1.5K citations

, , +10

Macmolplt: a graphical user interface for GAMESS

Brett Bode, Mark S. Gordon · Journal of Molecular Graphics and Modelling · 1998 · 1.1K citations

, , +12

The cdk5/p35 kinase is essential for neurite outgrowth during neuronal differentiation.

Margareta Nikolić, Henryk Dudek, Young T. Kwon et al. · Genes & Development · 1996 · 600 citations · Full text

, , +12

Antineoplastic agents. Par 108. Structural biochemistry. Part 23. Synthesis of the dolastatin thiazole amino acid component (gln)Thz

Cedric W. Holzapfel, George R. Pettit · The Journal of Organic Chemistry · 1985 · 61 citations

, , +7