Isoxazolylthioamides as potential immunosuppressants a combinatorial chemistry approach

The Immunosuppressive Metabolite of Leflunomide Is a Potent Inhibitor of Human Dihydroorotate Dehydrogenase

June P. Davis, Gary A. Cain, William J. Pitts et al. · Biochemistry · 1996 · 294 citations

Medicine, Biochemistry, Pharmacology +13

Dihydroorotate Dehydrogenase Is a High Affinity Binding Protein for A77 1726 and Mediator of a Range of Biological Effects of the Immunomodulatory Compound

Richard A. Williamson, Christopher Yea, P.A. Robson et al. · Journal of Biological Chemistry · 1995 · 197 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +15

Two activities of the immunosuppressive metabolite of leflunomide, A77 1726

Xiulong Xu, James W. Williams, Haihua Gong et al. · Biochemical Pharmacology · 1996 · 140 citations

Medicine, Medicinal Chemistry, Pharmacology +11

The crystal structure of the flavin containing enzyme dihydroorotate dehydrogenase A from Lactococcus lactis

Paul Rowland, F. S. NIELSEN, Kaj Frank Jensen et al. · Structure · 1997 · 99 citations · Full text

Life Sciences, Biochemistry, Microbiology +12

Thiocyclosporins: Preparation, Solution and Crystal Structure, and Immunosuppressive Activity

Dieter Seebàch, Soo Y. Ko, Horst Kessler et al. · Helvetica Chimica Acta · 1991 · 92 citations

Natural Sciences, Chemistry, Medicinal Chemistry +8