Two activities of the immunosuppressive metabolite of leflunomide, A77 1726

Genistein, a specific inhibitor of tyrosine-specific protein kinases.

Tetsu Akiyama, Junko Ishida, Shizue Nakagawa et al. · Journal of Biological Chemistry · 1987 · 3.7K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +15

Inhibitory effects of the tyrosine kinase inhibitor genistein on mammalian DNA topoisomerase II.

Judit Markovits, Claude Linassier, Philippe Fossé et al. · PubMed · 1989 · 552 citations

Medicine, Molecular Biology, Oncology +15

A lymphocyte-specific protein-tyrosine kinase gene is rearranged and overexpressed in the murine T cell lymphoma LSTRA

Jamey D. Marth, Richard Peet, Edwin G. Krebs et al. · Cell · 1985 · 542 citations · Full text

Life Sciences, Molecular Biology, Molecular Genetics +14

The immunosuppressant leflunomide inhibits lymphocyte proliferation by inhibiting pyrimidine biosynthesis.

Holly Cherwinski, Ronald G. Cohn, Ppy Cheung et al. · Journal of Pharmacology and Experimental Therapeutics · 1995 · 225 citations

Medicine, Immunology, Pharmacology +17

Inhibition of Protein Tyrosine Phosphorylation in T Cells by a Novel Immunosuppressive Agent, Leflunomide

Xiulong Xu, James W. Williams, Eric G. Bremer et al. · Journal of Biological Chemistry · 1995 · 218 citations · Full text

Medicine, Immunology, Pharmacology +17