Concepedia

CCR2B receptor antagonists: conversion of a weak HTS hit to a potent lead compound

Ian T. Forbes, David G. Cooper, Emma K. Dodds, Deirdre M. B. Hickey, Robert J. Ife, Malcolm L. Meeson, Martin L. Stockley, Theo A. Berkhout, Jayneeta Gohil, Pieter H.E. Groot,

Bioorganic & Medicinal Chemistry Letters · 2000 · 53 citations · 6 references

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6

Decreased lesion formation in CCR2−/− mice reveals a role for chemokines in the initiation of atherosclerosis

Landin Boring, Jennifa Gosling, Michael D. Cleary et al. · Nature · 1998 · 2K citations

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A small-molecule, nonpeptide CCR5 antagonist with highly potent and selective anti-HIV-1 activity

Masanori Baba, Osamu Nishimura, Naoyuki Kanzaki et al. · Proceedings of the National Academy of Sciences · 1999 · 755 citations

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Molecular cloning and functional expression of two monocyte chemoattractant protein 1 receptors reveals alternative splicing of the carboxyl-terminal tails.

Israel Charo, Scott J. Myers, A. G. Herman et al. · Proceedings of the National Academy of Sciences · 1994 · 717 citations

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MCP-1 deficiency reduces susceptibility to atherosclerosis in mice that overexpress human apolipoprotein B

Jennifa Gosling, Sarah Slaymaker, Long Gu et al. · Journal of Clinical Investigation · 1999 · 662 citations · Full text

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An Antagonist of Monocyte Chemoattractant Protein 1 (MCP-1) Inhibits Arthritis in the MRL-<i>lpr</i> Mouse Model

Jiang-Hong Gong, Leslie G. Ratkay, J. Douglas Waterfield et al. · The Journal of Experimental Medicine · 1997 · 379 citations

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