Nature · 2003 · 1.3K citations · 15 references
MedicineCancer BiologyOncologyCarcinogenesisCell SignalingMolecular OncologyColorectal CancerEpithelial TumorsGastric CancerHedgehog SignalingMetastatic Gastrointestinal CancerPancreatic CancerHedgehog MedicineHedgehog Signal Transduction In DevelopmentHedgehog Signaling ComplexesHedgehog Signaling In ProliferationSignal Transduction In Hedgehog Pathway
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Altered Neural Cell Fates and Medulloblastoma in Mouse <i>patched</i> Mutants
Lisa V. Goodrich, Ljiljana Milenković, Kay M. Higgins et al. · Science · 1997 · 1.7K citations
Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened
James Chen, Jussi Taipale, Michael K. Cooper et al. · Genes & Development · 2002 · 1.5K citations · Full text
Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine
Jussi Taipale, James Chen, Michael K. Cooper et al. · Nature · 2000 · 1.3K citations
Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer
D. Neil Watkins, David M. Berman, Scott G. Burkholder et al. · Nature · 2003 · 1.1K citations