Nature · 2003 · 1.1K citations · 24 references
Life SciencesCell BiologyOncologyCarcinogenesisCell SignalingMolecular OncologyEpithelial DifferentiationEpithelial MorphogenesisEpithelial TumorsHedgehog SignalingLung CancerOncogenic Signaling PathwaysHedgehog Signal Transduction In DevelopmentHedgehog Signaling In DifferentiationHedgehog Signaling In ProliferationHedgehog Target Gene RegulationSignal Transduction In Hedgehog Pathway
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Altered Neural Cell Fates and Medulloblastoma in Mouse <i>patched</i> Mutants
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Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened
James Chen, Jussi Taipale, Michael K. Cooper et al. · Genes & Development · 2002 · 1.5K citations · Full text
Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine
Jussi Taipale, James Chen, Michael K. Cooper et al. · Nature · 2000 · 1.3K citations