Concepedia

Nuclear factor p65 interacts with Keap1 to repress the Nrf2-ARE pathway

Miao Yu, Hui Li, Qiongming Liu, Fang Liu, Liujun Tang, Chang‐Yan Li, Yanzhi Yuan, Yi‐Qun Zhan, Wang‐Xiang Xu, Wei Li,

Cellular Signalling · 2011 · 309 citations · 31 references

DOI

Concepts

References

31

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

Ken Itoh, Nobunao Wakabayashi, Yasutake Katoh et al. · Genes & Development · 1999 · 3.6K citations · Full text

, , +16

Oxidative Stress Sensor Keap1 Functions as an Adaptor for Cul3-Based E3 Ligase To Regulate Proteasomal Degradation of Nrf2

Akira Kobayashi, Moon-Il Kang, Hiromi Okawa et al. · Molecular and Cellular Biology · 2004 · 2.2K citations · Full text

, , +17

Keap1-dependent Proteasomal Degradation of Transcription Factor Nrf2 Contributes to the Negative Regulation of Antioxidant Response Element-driven Gene Expression

Michael McMahon, Ken Itoh, Masayuki Yamamoto et al. · Journal of Biological Chemistry · 2003 · 1.1K citations · Full text

, , +12

Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis

Rajesh K. Thimmulappa · Journal of Clinical Investigation · 2006 · 1K citations · Full text

, , +17

Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation

Nobunao Wakabayashi, Ken Itoh, Junko Wakabayashi et al. · Nature Genetics · 2003 · 888 citations

, , +11