The influence of the P-glycoprotein inhibitor zosuquidar trihydrochloride (LY335979) on the brain penetration of paclitaxel in mice

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

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P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs.

Alfred H. Schinkel, Els Wagenaar, Carla A.A.M. Mol et al. · Journal of Clinical Investigation · 1996 · 1.3K citations · Full text

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Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine

Alex Sparreboom, Judith van Asperen, Ulrich Mayer et al. · Proceedings of the National Academy of Sciences · 1997 · 880 citations

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Pharmacological Inhibition of P-glycoprotein Transport Enhances the Distribution of HIV-1 Protease Inhibitors into Brain and Testes

Edna F. Choo, Brenda F. Leake, Christoph Wandel et al. · Drug Metabolism and Disposition · 2000 · 394 citations · Full text

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MW/Pharm, an integrated software package for drug dosage regimen calculation and therapeutic drug monitoring

Johannes H. Proost, Dirk K. F. Meijer · Computers in Biology and Medicine · 1992 · 333 citations · Full text

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