Hedgehog signaling patterns mesoderm in the sea urchin

Sonic hedgehog mediates the polarizing activity of the ZPA

Robert D. Riddle, Randy L. Johnson, Ed Laufer et al. · Cell · 1993 · 2.3K citations

Life Sciences, Cell Biology, Developmental Biology +10

Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity

Yann Echelard, Douglas J. Epstein, Benoit St‐Jacques et al. · Cell · 1993 · 2.2K citations

Life Sciences, Neurobiology, Neuroscience +13

Activating Smoothened mutations in sporadic basal-cell carcinoma

Jingwu Xie, Maximilien Murone, Shiuh-Ming Luoh et al. · Nature · 1998 · 1.3K citations

Veterinary Medicine, Genetics, Oncology +10

Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine

Jussi Taipale, James Chen, Michael K. Cooper et al. · Nature · 2000 · 1.3K citations

Medicine, Cancer Biology, Oncology +9

A functionally conserved homolog of the Drosophila segment polarity gene hh is expressed in tissues with polarizing activity in zebrafish embryos

Jean‐Paul Concordet, Philip W. Ingham · Cell · 1993 · 1.1K citations

Life Sciences, Developmental Biology, Genetics +14